Glutamate spillover drives robust all-or-none dendritic plateau potentials—an in silico investigati using models of striatal projection neurons

Plateau potentials are a critical feature of neuronal excitability, but their all-or-none behavior is not easily captured in modeling. In this study, we investigated models plateau multi-compartment neuron and found that including glutamate spillover provides robust behavior. This result arises due to the prolonged duration extrasynaptic glutamate. When included, very sensitive steepness Mg 2+ block. These results suggest potentially significant role potential generation, providing mechanism for across wide range slopes block curve. We also illustrate importance nonlinear computation with regard binding problem.